The Rosary Bead changes this to a 75%/25% chance of an angel or devil room (respectively), When Isaac takes damage, there is a chance he will gain the Gamekid effect, turning him invincible and dealing contact damage to any enemies he touches, The chance to activate the invincibility effect is affected by your luck stat and at +38 Luck it will activate every time you get hit, * , the lost item pool, nes, game, grey, gray, Tears shrink and grow in size as they go across the room, Does not appear to affect your damage and only the hitbox size of tears, Tears now move in a wave fashion across the room, While held, tears move in a spiral pattern across the screen at high speed, Effectively increases your range due to the tear pattern, Tears become flat and disc shaped giving them a larger hitbox, While this trinket is held, all items in the Shop cost 0 coins, After buying any 0 cent item in the Shop, the trinket disappears, UNLOCK: Unlock this item by beating the Chest with Lazarus, *, grey, gray, dollar, bill, note, cash, money, Isaac no longer takes damage from walking over spikes and blood creep while this trinket is held, * , the lost item pool, brown, pink, lump, ball, spot, 33% chance to drop a coin for every rock that you destroy, REPENTANCE - Previously was 100%, now 33%, UNLOCK: Unlock this item by destroying 100 rocks, Mom's Leg will now appear every 20 seconds and stomp down randomly in the room dealing 300 damage to enemies. yellow book how to, * boss room pool, boss room item, bone, red, brown, Gives Isaac a random tarot card when picked up, * boss room pool, boss room item, eight, grey, gray, Drops 4 random pills on the floor around Isaac, Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar, Mom's Chest, * dungeon room, blood challenge room, arena pool, demon beggar pool, demon judgement pool, devil beggar pool, normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, boss room pool, boss room item, shop room pool, shop item pool, bag, pouch, moms coin purse, mom coin purse. Honestly, Repentance probably adds the fewest "bad" unlocks out of any version of isaac ever. Though it's hard to narrow down the best, these ones are stellar. Flies spawned from a Mulligan dying, When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing, The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times, The spike wave will deal 10 damage to any enemies in contact with it. Part Two Second Knife Piece. UNLOCK: Unlock this trinket by collecting three of the following in the same run: Magic 8 Ball, Tiny Planet, Crystal Ball, Star of Bethlehem or any of the Astrology-related items (e.g. Based on the Steam Workshop mod created by Eufuu, UNLOCK: Unlock this trinket by having a lot of blue flies at once, While held this trinket gives your familiars homing shots, Added as part of the Afterbirth+ Booster Pack #5. Holding this trinket increase that chance by +15%. devil room pool, devil deal, grey, gray, hood, Isaac now has a small chance to create friendly attack spiders everytime he fires a tear, Can create up to a maximum of 5 spiders in the room at one time, The Hive Mind item allows Mom's Wig to spawn a maximum of 10 spiders at once, and increases their damage, The chance to create a spider is affected by your luck stat and at +10 Luck it will activate every time, * dungeon room, blood challenge room, arena pool, item room, treasure room, item room pool, Caves 2: 1 Boss Item + 2 Soul Hearts, Depths 1: 4 Soul hearts. can t use carpenter's workbench skyrim; how long does it take a rat to starve to death; cowboy hat making supplies; why would i get a letter from circuit clerk The Red Key item is required to access it, but it shows the direction to get there, UNLOCK: Unlock this item by defeating The Beast as Eve, Upon entering each new floor, if you have one red heart or less, another one is added, This effect works while moving up floors in the backwards path, This item has no effect for characters with non-red health i.e. the lost item pool, purple, cross, Item Pool: Curse Room, Devil Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, red, 666, Item Pool: Devil Room, Curse Room, Demon Beggar, * curse room pool, devil pool, devil room pool, devil deal, piece of paper, bloody paper, contract, With Keeper's buff of an additional Coin Heart, unlocking this item isn't that difficult compared to what it would have been in AB+. Void tears that touch enemies will spawn Big Horn, who appears and grabs them, instantly killing that enemy, The chance to for each tear to become a void tear is affected by your luck stat and at +15 Luck it will activate 20% of the time, Isaac also grows a horn on his head, which causes you to deal contact damage to enemies by running into them (this effect deals base damage of 3.5 per tick), Void tears from this item can also destroy blue/purple fires, spiked blocks and stone grimaces, When used, will spawn a fly turret that doesn't move and fires tears at nearby enemies, The fly's bullets deal 3.5 damage each and do not scale with your own damage stat. The Lost starts with this item after donating 879 coins to the Greed Donation Machine. Sales can be randomly applied just like regular shops, The ladder disappears after leaving the starting room, even if you haven't used it yet, In Antibirth this was called Jacob's Ladder, which had to be renamed as Afterbirth+ already had an item with this name, UNLOCK: Unlock this item by defeating Isaac as Jacob & Esau, Permanently shows the location of the boss room on the map, After defeating the shown boss fight, this item will activate a use of the Sun card (full heal and map reveal), fully recharge your active item, remove curses from the floor, gives +3 Damage Up and +1 Luck up for the rest of the floor, Only available inside a Planetarium - a room that has a base 1% chance to appear, which increases by +20% every time you skip an Item Room (Must not enter to count as skipped), In The Void floor it shows a random boss room, which isn't necessarily Delirium's room, Adds one extra secret room and one extra super secret room to each floor. Gives Isaac a little portal familiar, that moves across the screen as you're firing, The portal will suck up any consumables and trinkets it travels over, causing it to become larger and deal more contact damage, When the portal sucks up 4 pickups, it turns into a portal that can be used to teleport to unexplored rooms around the floor. It also no longer prevents damage from self-harming mechanics e.g. This room basically serves as a consolation prize if you fail to get keys to drop, but it also makes Ascension runs much easier, because you can skip Item Rooms to get a Planetarium, but pick up the skipped items as you ascend back up to Home. It will also sometimes randomly drop bombs. 's unique poops, Corn poop - Spawns a blue fly every 2 seconds, Flaming poop - Leaves behind fire that damages enemies, Black poop - Creates slowing black creep. arrow, Causes your friendly blue spiders and flies to become bigger and do x2 more damage, Allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5, Fly and spider familiars become stronger similar to BFFS, * shop room pool, shop item pool, blue, fat, Two items now spawn after beating a boss fight and the boss rush, however only one can be taken, The additional item will pick from the Boss Item Pool, Unlocked by donating to the donation machine in the shop, UNLOCK: Unlock this item by donating 50 pennies to the Shop, * shop room pool, shop item pool, white, question mark, square, theres options, * shop room pool, shop item pool, purple, paper, ticket, Isaac can now hold 2 cards or runes at once. ?s only friend, blue bozzy, An iron ball and chain attached to Isaac, similar to Guppy's Hairball that you can fling around to deal 5 damage per tick, The ball will block enemy shots and can also destroy environmental objects such as rocks, mushrooms and skulls, Does not decrease your movement speed stat at all however the ball has to be dragged around causing Isaac to slow down slightly when the chain is fully extended, UNLOCK: Unlock this item by beating Boss Rush with Samson, * secret room pool, item room, treasure room, item room pool, grey, gray, shackle, A familiar that will follow Isaac and copy the effect of one of your other familiars, If you don't have any other familiars, he will just shoot normal tears, REPENTANCE - Removed the double damage multiplier on Mongo Baby's attacks, * item room, treasure room, item room pool, pink, blue, grey, gray, An active item that fires 8 of Isaac's tears in a circle around him, Tears spawned from this item keep most effect that Isaac currently has applied to his tears, and deal an additional +5 flat damage, UNLOCK: Unlock this item by beating the Isaac boss with Isaac, * item room, treasure room, item room pool, glass, blue, water, isaacs tears, Upon use, teleports you to one of the following rooms at random: Item room, Secret room, Super secret room, the I AM ERROR room or the Black Market (very low chance), There are no I AM ERROR rooms on the final floors, preventing looping with this item, UNLOCK: Unlock this item by beating Boss Rush with Eden, * item room, treasure room, item room pool, pink, purple, red, broken, When used will cut your head from your body. UNLOCK: Unlock this item by beating Greed Mode with ??? The room doors will open if only frozen enemies remain, UNLOCK: Unlock this trinket by defeating challenge #41 (Pica Run), Every time you kill an enemy you get an invincibility shield for 1 second, While shielded, each enemy killed adds +1 seconds to the duration, UNLOCK: Unlock this trinket by defeating challenge #37 (Bloody Mary), * item room, treasure room, item room pool, green, cry, plant, Tears now shoot three at a time (Triple Shot). Shotgun Location Players can get the Shotgun from the location of the GPS Locator. You may see more or less than this on the Found HUD overlay, however this number varies based on your other damage increasing items. starting, blue, white, glow, cross, You can now break obstacles by walking over them, Holes in the ground can be filled by crushing adjacent rocks, similar to how this can be done with bombs, * item room, treasure room, item room pool, cheetos, cheese, grey, gray, orange, jar, Enemies and pickups (keys, bombs etc.) white, grey, gray moms pad, mom pad, A poison bomb which can be thrown and leaves a poison effect on any enemies within the blast radius. If any enemies walk into its path, it will deal 7 contact damage every 7 frames, Nearby enemies will be forced to target and attack it, If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle, Causes your bombs to explode into 2-4 tiny bombs, The smaller bombs deal half damage and have a smaller explosion area. Also summons a blue crosshair which can be moved around freely. ?, Satan and The Lamb as Tainted Lost. This allows Isaac to potentially accrue a large number of stat upgrades. Keys and bombs are equal to 3 coins for deciding which to give, Item Pool: Boss Room, Golden Chest, Crane Game, Grants a large orbital that rotates around Isaac, When the orbital takes a few hits, they split into two smaller ones, After the smaller orbitals take another hit, they explode into 2 blue spiders, This item will respawn after a period of time, UNLOCK: Unlock this item by defeating Mother in the Corpse II as Lazarus, Your bombs now explode and fire 4 Brimstone lasers in all cardinal directions, Each brimstone laser deals 8 damage per tick for 13 total hits, UNLOCK: Unlock this item by killing Hornfel before he can escape after breaking his minecart, Item Pool: Devil Room, Bomb Beggar, Greed Mode Devil Room, Active items no longer charge up as normal from clearing rooms, Enemies taking damage now charges your item instead. Replacing all 12 containers with broken hearts will kill you instantly. blue, glow, arrow, cross, * astrology, astronomy, item room, treasure room, item room pool, cyan, black, blue, glow, n, tail, Leaves a trail of tears on the floor behind Isaac which damages enemies that walk over it for 2 damage per tick, REPENTANCE - Aquarius now synergizes with tear effects, * astrology, astronomy, item room, treasure room, item room pool, black, blue, cyan, blue, glow, with Lilith, After picking up 15 hearts, Isaac gains a permanent angelic familiar and a soul heart drops, Possible familiars include: Holy Water, Guardian Angel, Sworn Protector, The Relic and Seraphim, It is possible to get multiple followers by continuing to pick up hearts, at intervals of 15 hearts each, After all 5 familiars have spawned, it will just drop a soul heart every 15 hearts collected, UNLOCK: Unlock this item by beating Boss Rush with Lilith, Two items now spawn in each of your item rooms, however only one can be taken and the other will disappear, A crown that replaces normal tears with blue diamond tears while you don't have any empty red heart containers or bone hearts, While the effect is active, tears do double damage and have -0.30 Shot Speed, The crown will glow blue while active, if inactive it will appear grey, The effect will also deactivate for the rest of the current room when you take damage, regardless of your health, When a room clear would otherwise yield no rewards, it now spawns 1-3 pennies, REPENTANCE - Deep Pockets no longer adds a pill/card slot, instead increases money cap to 999, UNLOCK: Unlock this item by beating The Chest floor with Keeper, A flying familiar that bounces around the room with a damaging aura, dealing rapid damage to any enemies inside it and boosting Isaac's tear damage, While standing in the black aura, Isaac has a temporary 1.5x damage multiplier (this will stack if you have more than one Succubus), The aura deals 2.5 damage per tick or about 7.5 - 10 damage per second, UNLOCK: Unlock this item by beating The Lamb with Lilith, Gives you a different tear effect with every tear that you fire, Tear effects include: Anti-Gravity, Ball of Bandages (Lvl 4), Bumbo (Lvl 3), Continuum, Cupid's Arrow, Compound Fracture, Euthanasia, Explosivo, Eye of Greed, Fire Mind, Flat Stone, Flat Worm, God's Flesh, Godhead, Head of the Keeper, Holy Light, Hook Worm, Ipecac, Iron Bar, Jacob's Ladder, Knockout Drops, Lachryphagy, Little Horn, Lodestone, Mom's Contacts, Mom's Eyeshadow, Mom's Perfume, Mucormycosis, My Reflection, Mysterious Liquid, Ocular Rift, Ouija Board, Ouroboros Worm, The Parasite, Parasitoid, Polyphemus, Pop!, Proptosis, Pulse Worm, Ring Worm, Rotten Tomato, Rubber Cement, Serpent's Kiss, Sinus Infection, Spider Bite, Strange Attractor, Sulfuric Acid, Technology Zero, Tiny Planet, Trisagion and Wiggle Worm, With Dr. Fetus, this item will also cycle through random Bomb Modifiers (e.g. The first and second familiars spawn after 15 hits, then 30 hits for the third and fourth, Cambion Conception cannot grant more than 4 familiars in total, UNLOCK: Unlock this item by beating ??? ?, Satan and The Lamb as Tainted Isaac, Every time you enter a brand new room, you have a chance to get a random one-time use Dice (e.g. Repentance introduces many new strong trinkets, but this is the only trinket that can directly help in achieving completion marks by making getting to Hush easier if you're lucky enough to get this. Those tears will cause the same effect if they happen to hit other enemies, Effects that replace your tears such as Brimstone simply have a chance to apply this effect, Any enemies that come within close range of Isaac will become feared, which causes them to flee, When used, this item takes away 5 of your coins and gives a +1.2 Damage Up that lasts for the current room, Can stack as many times as you want. It also leaves a gas cloud at the place where it exploded, The bomb deals 185 damage + your tear damage on hit and leaves a damage over time poison effect that does 3 times your tear damage per tick, Synergizes with tear modifying items such as My Reflection or Tiny Planet, Has a chance to drop from the Sloth miniboss fight, Counts as 1 of 3 poison items needed towards the Bob transformation, REPENTANCE - The damage of this item was significantly boosted to 185 (from 50) in Repentance, and given the poison cloud effect. Items picked up are not shared between the two characters, UNLOCK: Unlock this item by defeating The Beast as Tainted Jacob, When activated, Isaac's tears are replaced by a bone sword and he goes on a killing rampage, gaining +0.4 Speed, +3 Flat Damage Up for 5 seconds, The sword deals x3 damage if used at close range, or x1.5 damage if charged up and thrown, Clearing rooms doesn't charge this item - charge is added equal to damage taken by enemies. For the biggest and best experience, you'll want the Rebirth Complete Bundle on Steam, which includes the newer base game and all three expansions, clocking in at a hefty $51 when not on sale.. smile, lil' brimstone, Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around. Each secret room contains a beam of light, that gives half a soul heart, and a Tears Up for the rest of the floor. It can be anything including spawning a bunch of consumables, spawning a glitched pedestal item, creating a bunch of light beams, spawning troll bombs or nothing at all, UNLOCK: Unlock this item by defeating The Beast as Eden, "Isaac and his mother lived alone in a small house on a hill", When picked up, all future items become 'glitched', causing them to become random combinations of 2-3 effects based on other items, Glitched items can be passive or active and are completely randomly generated with infinite possibilities (similar to other 'Randomizer' games), The ratio of active to passive item effects given is 1/4, Random effects combine effects that exist on other items, and assign them to a random event (e.g. Depths 2: 20 coins, Sheol: 1 Devil Room Item + 1 Black Heart. These can be smaller or big batteries, Upon use, Mom's Bracelet allows you to grab objects in the room and throw them, damaging any enemies which are hit for 40 damage, Most objects can be thrown including pots, rocks, poops, tnt etc, Pressing the activate button again will drop the object where you stand, which doesn't consume a charge of use, Allows you to remove the skull on top of Host enemies, turning them into the red version, Counts as 1 of 3 mom items needed towards the Mom transformation, *, arm, moms, ring, bracers, zelda, gold band, golden band, power bracelet, When used, this item spawns a Peeper familiar for the current room, which deals 12 contact damage per tick to enemies and leaves red creep in its path, Using this item removes Isaac's right eye, causing tears from this eye to deal x1.5 your normal tear damage, Using it more than once in the same room will spawn multiple Peeper familiars, Fired tears now have a chance to summon a rift when they land on the ground, The spawned rift sucks in enemies, projectiles and pickups and deals damage to enemies caught inside for 2 seconds, The chance to fire the rift tear can improve based on your luck stat. : 1 Devil Room item + 1 Black Heart Mode with??????... ; unlocks out of any version of isaac ever potentially accrue a large number of stat upgrades Black.. 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